Manka, P, Coombes, JD, Boosman, R et al. (3 more authors) (2018) Thyroid hormone in the regulation of hepatocellular carcinoma and its microenvironment. Cancer Letters, 419. pp. 175-186. ISSN 0304-3835
Abstract
Hepatocellular carcinoma (HCC) commonly arises from a liver damaged by extensive inflammation and fibrosis. Various factors including cytokines, morphogens, and growth factors are involved in the crosstalk between HCC cells and the stromal microenvironment. Increasing our understanding of how stromal components interact with HCC and the signaling pathways involved could help identify new therapeutic and/or chemopreventive targets. It has become increasingly clear that the cross-talk between tumor cells and host stroma plays a key role in modulating tumor growth. Emerging reports suggest a relationship between HCC and thyroid hormone signaling (dysfunction), raising the possibility that perturbed thyroid hormone (TH) regulation influences the cancer microenvironment and cancer phenotype. This review provides an overview of the role of thyroid hormone and its related pathways in HCC and, specifically, its role in regulating the tumor microenvironment.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2018, Elsevier B.V. All rights reserved. This is an author produced version of a paper published in Cancer Letters. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Thyroid hormone; Liver cancer; Tumor microenvironment; Liver fibrogenesis |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Experimental Haematology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 06 Mar 2018 12:27 |
Last Modified: | 28 Feb 2019 01:38 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.canlet.2018.01.055 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:128189 |