Kwok, CJ orcid.org/0000-0002-9798-9083, Afshari, F, Garcia-Alias, G et al. (1 more author) (2008) Proteoglycans in the central nervous system: plasticity, regeneration and their stimulation with chondroitinase ABC. Restorative Neurology and Neuroscience, 26 (2-3). pp. 131-145. ISSN 0922-6028
Abstract
After injury to the mammalian central nervous system (CNS), neurons are not able to regenerate their axons and recovery is limited by restricted plasticity. Axon regeneration is inhibited by the presence of the various inhibitory molecules, including chondroitin sulfate proteoglycans (CSPGs) which are upregulated around the injury site. Plasticity after the end of critical periods is restricted by extracellular matrix changes, particularly the formation of CSPG-containing perineuronal nets. Enzymatic removal of chondroitin sulfate (CS) chains with chondroitinase ABC promotes axon regeneration and reactivates plasticity. This review details the structures and properties of the different CSPGs in the normal and damaged CNS, the use of the enzyme chondroitinase ABC to promote neural regeneration and plasticity, and discusses mechanisms of action and possible therapeutic uses of this enzyme.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | Chondroitin sulfate; Chondroitinase ABC; CNS injury |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 08 Mar 2018 15:18 |
Last Modified: | 08 Mar 2018 15:18 |
Status: | Published |
Publisher: | IOS Press |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:128102 |