Sabbadin, Federico, Hemsworth, Glyn R. orcid.org/0000-0002-8226-1380, Ciano, Luisa orcid.org/0000-0002-1667-0856 et al. (17 more authors) (2018) An ancient family of lytic polysaccharide monooxygenases with roles in arthropod development and biomass digestion. Nature Communications. 756. ISSN 2041-1723
Abstract
Thermobia domestica belongs to an ancient group of insects and has a remarkable ability to digest crystalline cellulose without microbial assistance. By investigating the digestive proteome of Thermobia, we have identified over 20 members of an uncharacterized family of lytic polysaccharide monooxygenases (LPMOs). We show that this LPMO family spans across several clades of the Tree of Life, is of ancient origin, and was recruited by early arthropods with possible roles in remodeling endogenous chitin scaffolds during development and metamorphosis. Based on our in-depth characterization of Thermobia's LPMOs, we propose that diversification of these enzymes toward cellulose digestion might have endowed ancestral insects with an effective biochemical apparatus for biomass degradation, allowing the early colonization of land during the Paleozoic Era. The vital role of LPMOs in modern agricultural pests and disease vectors offers new opportunities to help tackle global challenges in food security and the control of infectious diseases.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Biology (York) > Centre for Novel Agricultural Products (CNAP) (York) The University of York > Faculty of Sciences (York) > Biology (York) The University of York > Faculty of Sciences (York) > Chemistry (York) |
Funding Information: | Funder Grant number BBSRC (BIOTECHNOLOGY AND BIOLOGICAL SCIENCES RESEARCH COUNCIL) BB/L001926/1 EPSRC EP/M028127/1 |
Depositing User: | Pure (York) |
Date Deposited: | 21 Feb 2018 17:30 |
Last Modified: | 08 Feb 2025 00:26 |
Published Version: | https://doi.org/10.1038/s41467-018-03142-x |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1038/s41467-018-03142-x |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:127838 |
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