Frood, R, Prestwich, R, Tsoumpas, C orcid.org/0000-0002-4971-2477 et al. (3 more authors) (2018) Effectiveness of Respiratory-gated Positron Emission Tomography/Computed Tomography for Radiotherapy Planning in Patients with Lung Carcinoma – A Systematic Review. Clinical Oncology, 30 (4). pp. 225-232. ISSN 0936-6555
Abstract
Aims; A systematic review of the literature evaluating the clinical use of respiratory-gated (four-dimensional; 4D) fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) compared with non-gated (three-dimensional; 3D) PET/CT for radiotherapy planning in lung cancer. Materials and methods; A search of MEDLINE, Cochrane, Web of Science, SCOPUS and clinicaltrials.gov databases was undertaken for articles comparing 3D and 4D PET/CT tumour volume or 4D PET/CT for radiotherapy planning. PRISMA guidelines were followed. Results; Thirteen studies compared tumour volumes at 3D and 4D PET/CT; eight reported significantly smaller volumes (6.9–44.5%), three reported significantly larger volumes at 4D PET/CT (16–50%), one reported no significant difference and one reported mixed findings. Six studies, including two that reported differences in tumour volumes, compared target volumes or studied geographic misses. 4D PET/CT target volumes were significantly larger (19–40%) when compared with 3D PET/CT in all but one study, where they were smaller (3.8%). One study reported no significance in 4D PET/CT target volumes when compared with 4D CT, whereas another study reported significantly larger volumes (38.7%). Conclusion; The use of 4D PET/CT leads to differences in target volume delineation compared with 3D PET/CT. These differences vary depending upon technique and the clinical impact currently remains uncertain. Correlation of pretreatment target volumes generated at 3D and 4D PET/CT with postsurgical histology would be ideal but technically challenging. Evaluation of patient outcomes based on 3D versus 4D PET/CT derived treatment volumes warrants further investigation.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 The Royal College of Radiologists. This is an author produced version of a paper published in Clinical Oncology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | FDG PET/CT lung cancer radiation therapy respiratory gating systematic review |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Inst of Biomed & Clin Sciences (LIBACS) (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 23 Feb 2018 10:17 |
Last Modified: | 01 Feb 2019 01:49 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.clon.2018.01.005 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:127799 |
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Filename: 4D PETCT for radiotherapy planning in NSCLC - Figures and tables included.pdf
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