Roy, Soumya S. orcid.org/0000-0002-9193-9712, Appleby, Kate M., Fear, Elizabeth J. et al. (1 more author) (2018) SABRE-Relay:A Versatile Route to Hyperpolarization. JOURNAL OF PHYSICAL CHEMISTRY LETTERS. jz-2017-03026f.R3. pp. 1112-1117. ISSN 1948-7185
Abstract
Signal Amplification by Reversible Exchange (SABRE) is used to switch on the latent singlet spin order of para-hydrogen (p-H2) so that it can hyperpolarize a substrate (sub = nicotinamide, nicotinate, niacin, pyrimidine and pyrazine). The substrate then reacts reversibly with [Pt(OTf)2(bis-diphenylphosphinopropane)] by displacing OTf- to form [Pt(OTf)(sub)(bis-diphenylphosphinopropane)]OTf. The 31P NMR signals of these metal complexes prove to be enhanced when the substrate possesses an accessible singlet state or long-lived Zeeman polarization. In the case of pyrazine, the corresponding 31P signal was 105 ± 8 times larger than expected, which equated to an 8-hour reduction in total scan time for an equivalent signal to noise ratio under normal acquisition conditions. Hence p-H2 derived spin order is successfully relayed into a second metal complex via a suitable polarization carrier (sub). When fully developed we expect this route involving a second catalyst to successfully hyperpolarize many classes of substrate that are not amenable to normal SABRE.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © American Chemical Society. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) The University of York |
Funding Information: | Funder Grant number WELLCOME TRUST 098335/Z/12/Z EUROPEAN COMMISSION 642773 |
Depositing User: | Pure (York) |
Date Deposited: | 13 Feb 2018 15:40 |
Last Modified: | 07 Jan 2025 00:10 |
Published Version: | https://doi.org/10.1021/acs.jpclett.7b03026 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1021/acs.jpclett.7b03026 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:127412 |