Evans-Cheung, TC orcid.org/0000-0003-0899-5383, Bodansky, HJ, Parslow, RC orcid.org/0000-0002-3945-5294 et al. (1 more author) (2018) Early deaths from ischaemic heart disease in childhood-onset type 1 diabetes. Archives of Disease in Childhood, 103 (10). pp. 981-983. ISSN 0003-9888
Abstract
Aims
The risk of ischaemic heart disease (IHD) death in early type 1 diabetes onset was assessed using death certification data.
Methods
The Yorkshire Register of type 1 Diabetes in Children and Young People was linked to clinically validated death certification data for those diagnosed under 15 years. Standardised mortality ratios (SMRs) were calculated using the England and Wales population and IHD death rates between 1978 and 2014 by 5-year age group and sex.
Results
The cohort included 4382 individuals (83 097 person years). Of 156 deaths, nine were classed as IHD deaths before clinical validation. After clinical validation, 14 IHD deaths were classified, with an SMR of 13.8 (95% CI 8.2 to 23.3) and median age at death of 35.1 years (range 21.9–47.9 years).
Conclusions
There is an early emergence of death from IHD in early onset type 1 diabetes. Underascertainment of IHD deaths was present without clinical validation of death certification.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Authors (or their employers) 2018. Published by BMJ Publishing Group Ltd (& RCPCH) under licence. This is an author produced version of a paper published in Archives of Disease in Childhood. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | diabetes; epidemiology |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) |
Funding Information: | Funder Grant number Department of Health NOT GIVEN Leeds Teaching Hospitals NHS Trust Not Known Leeds Teaching Hospitals NHS Trust No Ext Ref Given |
Depositing User: | Symplectic Publications |
Date Deposited: | 09 Feb 2018 11:58 |
Last Modified: | 28 Sep 2018 14:34 |
Status: | Published |
Publisher: | BMJ Publishing Group |
Identification Number: | 10.1136/archdischild-2017-314265 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:127074 |