Speight, P.M., Khurram, S.A. orcid.org/0000-0002-0378-9380 and Kujan, O. (2018) Oral potentially malignant disorders: Risk of progression to malignancy. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 125 (6). pp. 612-627. ISSN 2212-4403
Abstract
© 2017 Elsevier Inc. Oral potentially malignant disorders (OPMDs) have a statistically increased risk of progressing to cancer, but the risk varies according to a range of patient- or lesion-related factors. It is difficult to predict the risk of progression in any individual patient, and the clinician must make a judgment based on assessment of each case. The most commonly encountered OPMD is leukoplakia, but others, including lichen planus, oral submucous fibrosis, and erythroplakia, may also be seen. Factors associated with an increased risk of malignant transformation include sex; site and type of lesion; habits, such as smoking and alcohol consumption; and the presence of epithelial dysplasia on histologic examination. In this review, we attempt to identify important risk factors and present a simple algorithm that can be used as a guide for risk assessment at each stage of the clinical evaluation of a patient.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 Elsevier. This is an author produced version of a paper subsequently published in Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. Uploaded in accordance with the publisher's self-archiving policy. Article available under the terms of the CC-BY-NC-ND licence (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Clinical Dentistry (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 08 Feb 2018 10:48 |
Last Modified: | 25 Nov 2020 11:55 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | 10.1016/j.oooo.2017.12.011 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:127051 |
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