Blakey, K, Feltbower, RG orcid.org/0000-0002-1728-9408, James, PW et al. (5 more authors) (2018) Socio-economic patterning in early mortality of patients aged 0-49 years diagnosed with primary bone cancer in Great Britain, 1985-2008. Cancer Epidemiology, 53. pp. 49-55. ISSN 1877-7821
Abstract
Background: Studies have shown marked improvements in survival between 1981 and 2000 for Ewing sarcoma patients but not for osteosarcoma. This study aimed to explore socio-economic patterning in early mortality rates for both tumours. Procedure: The study analysed all 2432 osteosarcoma and 1619 Ewing sarcoma cases, aged 0-49 years, diagnosed in Great Britain 1985-2008 and followed to 31/12/2009. Logistic regression models were used to calculate risk of dying within three months, six months, one year, three years and five years after diagnosis. Associations with Townsend deprivation score and its components were examined at small-area level. Urban/rural status was studied at larger regional level. Results: For osteosarcoma, after age adjustment, mortality at three months, six months and one year was associated with higher area unemployment, OR = 1·05 (95% CI 1·00, 1·10), OR = 1·04 (95% CI 1·01, 1·08) and OR = 1·04 (95% CI 1·02, 1·06) respectively per 1% increase in unemployment. Mortality at six months was associated with greater household non-car ownership, OR = 1·02 (95% CI 1·00, 1·03). For Ewing sarcoma, there were no significant associations between mortality and overall Townsend score, nor its components for any time period. For both tumours increasing mortality was associated with less urban and more remote rural areas. Conclusions: This study found that for osteosarcoma, early mortality was associated with residence at diagnosis in areas of higher unemployment, suggesting risk of early death may be socio-economically determined. For both tumours, distance from urban centres may lead to greater risk of early death.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 Elsevier Ltd. This is an author produced version of a paper published in Cancer Epidemiology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Early mortality; Ewing sarcoma; Great Britain; Osteosarcoma; Primary bone cancer; Socio-economic patterning |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Geography (Leeds) > Centre for Spatial Analysis & Policy (Leeds) |
Funding Information: | Funder Grant number Candlelighters No Ext Ref Given |
Depositing User: | Symplectic Publications |
Date Deposited: | 06 Feb 2018 11:16 |
Last Modified: | 04 Feb 2019 01:40 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.canep.2018.01.012 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:127034 |