Li, YJ, Wu, K, Li, Y et al. (3 more authors) (2018) Solubility in Different Solvents, Crystal Polymorph and Morphology, and Optimization of Crystallization Process of AIBN. Journal of Chemical and Engineering Data, 63 (1). pp. 27-38. ISSN 0021-9568
Abstract
The solubility of 2,2′-azobisisobutyronitrile (AIBN) in pure methanol, ethanol, acetone, benzene, ethyl acetate, and a mixture of methanol and water was measured in the temperature range from 268.15 to 325.15 K at atmospheric pressure. The AIBN solubility was sensitive to the temperature in all pure solvents. The solubility in the binary mixture of methanol and water increased as the methanol fraction and temperature increased. The data were correlated with the modified Apelblat, Van't Hoff, and Buchowski-Ksiazczak λh equations. Other results showed that two AIBN polymorphs formed after the crystallization: form I, in a monoclinic cell, and form II, in a triclinic cell, which confirmed the two AIBN crystal structures reported in the literature. Additionally, the initial concentration and cooling rate of the AIBN crystallization had dominant roles in affecting the polymorphic forms of the AIBN crystals. The crystallization conditions were optimized in a 2 L crystallizer to yield crystals with the desire d morphology and polymorphs, which resolved the caking issue experienced in the industrial production of AIBN. The optimized conditions were tested in a 20 L crystallizer.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2017, American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in the Journal of Chemical and Engineering Data, copyright (c) American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.jced.7b00538 |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemical & Process Engineering (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 06 Feb 2018 15:23 |
Last Modified: | 15 Nov 2018 01:39 |
Status: | Published |
Publisher: | American Chemical Society |
Identification Number: | 10.1021/acs.jced.7b00538 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:127032 |