Sharma, H., Smith, D., Turner, C.E. orcid.org/0000-0002-4458-9748 et al. (6 more authors) (2018) Clinical and Molecular Epidemiology of Staphylococcal Toxic Shock Syndrome in the United Kingdom. Emerging Infectious Diseases, 24 (2). ISSN 1080-6040
Abstract
Staphylococcal toxic shock syndrome (TSS) was originally described in menstruating women and linked to TSS toxin 1 (TSST-1)-producing Staphylococcus aureus. Using UK national surveillance data, we ascertained clinical, molecular and superantigenic characteristics of TSS cases. Average annual TSS incidence was 0.07/100,000 population. Patients with nonmenstrual TSS were younger than those with menstrual TSS but had the same mortality rate. Children <16 years of age accounted for 39% of TSS cases, most caused by burns and skin and soft tissue infections. Nonmenstrual TSS is now more common than menstrual TSS in the UK, although both types are strongly associated with the tst+ clonal complex (CC) 30 methicillin-sensitive S. aureus lineage, which accounted for 49.4% of all TSS and produced more TSST-1 and superantigen bioactivity than did tst+ CC30 methicillin-resistant S. aureus strains. Better understanding of this MSSA lineage and infections in children could focus interventions to prevent TSS in the future.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 Centers for Disease Control and Prevention. Reproduced in accordance with the publisher's self-archiving policy. Available under the Creative Commons licence https://creativecommons.org/licenses/by/4.0/. |
Keywords: | CC30; MRSA and other staphylococci; Staphylococcus aureus; TSST-1; United Kingdom; antimicrobial resistance; bacteria; ccpA; staphylococcal toxic shock syndrome |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) > Department of Molecular Biology and Biotechnology (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 24 Jan 2018 15:57 |
Last Modified: | 24 Jan 2018 15:57 |
Published Version: | https://doi.org/10.3201/eid2402.170606 |
Status: | Published |
Publisher: | Centers for Disease Control and Prevention |
Refereed: | Yes |
Identification Number: | 10.3201/eid2402.170606 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:126574 |