Eastell, R. orcid.org/0000-0002-0323-3366 and Walsh, J.S. orcid.org/0000-0002-7122-2650 (2017) Anabolic treatment for osteoporosis: teriparatide. Clinical Cases in Mineral and Bone Metabolism, 14 (2). pp. 173-178. ISSN 1724-8914
Abstract
Teriparatide is a safe and effective anabolic treatment for osteoporosis. In postmenopausal women, it increases BMD and decreases vertebral fractures by about 70% and non-vertebral fractures by about 45% (although there is no evidence that it prevents hip fractures). The current evidence indicates that it should be administered for a single course of 24 months, and followed with an anti-resorptive agent to maintain the BMD gain. There is no clear benefit to repeated or cyclical treatment. Combination treatment, particularly with denosumab achieves greater BMD increase than either agent alone, but there are no available fracture data for combination treatment. There are some unknowns; most fundamentally why daily PTH administration is anabolic to bone when continuous high PTH is catabolic. Also, a better understanding of why the anabolic action declines with time and why there is a poor response to repeated treatment may help us to use teriparatide more effectively, and increase our understanding of bone biology and osteoporosis pathophysiology.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 CIC Edizioni Internazionali S.r.l. |
Keywords: | bone formation; bone mineral density; bone turnover markers; fracture; osteoporosis; teriparatide |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Division of Genomic Medicine (Sheffield) > Department of Oncology and Metabolism (Sheffield) The University of Sheffield > Sheffield Teaching Hospitals |
Funding Information: | Funder Grant number NATIONAL INSTITUTE FOR HEALTH RESEARCH UNSPECIFIED |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 18 Jan 2018 09:57 |
Last Modified: | 18 Jan 2018 09:57 |
Published Version: | https://doi.org/10.11138/ccmbm/2017.14.1.173 |
Status: | Published |
Publisher: | CIC Edizioni Internazionali |
Refereed: | Yes |
Identification Number: | 10.11138/ccmbm/2017.14.1.173 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:126303 |