Allen, KE, Bennett, PA and Orsi, NM (2018) Uterine adenosarcoma: a case-based review of the diagnostic features. Diagnostic Histopathology, 24 (1). pp. 45-47. ISSN 1756-2317
Abstract
Uterine (Müllerian) adenosarcomas are rare malignancies which account for 5% of uterine sarcomas. Most presentations are postmenopausal, and with early stage disease. This report highlights these entities' diagnostic features, namely having a neoplastic benign or mildly atypical epithelial component, and sarcomatous (often low-grade) stromal component. Architecturally, they resemble phyllodes tumour. Stromal projections are lined by benign or mildly atypical Müllerian-type epithelia. Heterologous elements may be present, or there may be sex cord-like differentiation. The stroma typically displays increased periepithelial cellularity (the characteristic ‘cambium’ layer) and a mitotic activity of two or more mitotic figures/10 high power fields. Immunohistochemical profile shows the stroma to be oestrogen receptor, CD10 and Wilm's tumour-1 positive, with strong immunoreactivity for P53 and Ki67 seen in cases with sarcomatous overgrowth, where CD10 and ER positivity is often lost.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2017 Published by Elsevier Ltd. This is an author produced version of a paper published in Diagnostic Histopathology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | adenosarcoma; histology; immunohistochemistry; uterus |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cancer and Pathology (LICAP) > Pathology & Tumour Biology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 11 Jan 2018 10:02 |
Last Modified: | 09 Jan 2019 01:38 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.mpdhp.2017.12.001 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:126128 |
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