Yu, D., Cai, Y., Graffy, J. et al. (3 more authors) (2018) Development and external validation of risk scores for cardiovascular hospitalization and rehospitalization in patients with diabetes. Journal of Clinical Endocrinology & Metabolism, 103 (3). pp. 1122-1129. ISSN 0021-972X
Abstract
Context Cardiovascular disease (CVD) is a common and costly reason for hospitalisation and re-hospitalisation among patients with type 2 diabetes.
Objective This study aimed to develop and externally validate two risk prediction models for cardiovascular hospitalisation and cardiovascular re-hospitalisation.
Design Two independent prospective cohorts.
Setting The derivation cohort includes 4,704 patients with type 2 diabetes from 18 general practices in Cambridgeshire. The validation cohort comprises 1,121 patients with type 2 diabetes from post-trial follow-up data.
Main Outcome Measure Cardiovascular hospitalisation over 2 years and cardiovascular re-hospitalisation after 90 days of the prior CVD hospitalisation.
Results The absolute rate of cardiovascular hospitalisation and re-hospitalisation was 12.5% and 6.7% in the derivation cohort, and 16.3% and 7.0% in the validation cohort. Discrimination of the models was similar in both cohorts, with C statistics above 0.70, and excellent calibration of observed and predicted risks.
Conclusion Two new prediction models that quantify risks of cardiovascular hospitalisation and re-hospitalisation have been developed and externally validated. They are based on a small number of clinical measurements that are available for patients with type 2 diabetes in many developed countries in primary care settings and could serve as the tools to screen the population at high risk of cardiovascular hospitalisation and re-hospitalisation.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 Endocrine Society. This is an author produced version of a paper subsequently published in Journal of Clinical Endocrinology & Metabolism. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Social Sciences (Sheffield) > Department of Sociological Studies (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 12 Jan 2018 11:49 |
Last Modified: | 11 Aug 2020 16:24 |
Status: | Published |
Publisher: | Oxford University Press |
Refereed: | Yes |
Identification Number: | 10.1210/jc.2017-02293 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:126091 |