Albazaz, R, Patel, CN, Chowdhury, FU et al. (1 more author) (2013) Clinical impact of FDG PET-CT on management decisions for patients with primary biliary tumours. Insights into Imaging, 4 (5). pp. 691-700. ISSN 1869-4101
Abstract
Objectives: To assess the impact on clinical management of introducing 18F-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET)-computed tomography (CT) in to the work-up of patients with primary and recurrent biliary malignancy.
Methods: Consecutive patients with primary biliary tumours undergoing FDG PET-CT at a single large tertiary referral centre between November 2007 and September 2010 were retrospectively analysed. Findings on FDG PET-CT compared with CT/magnetic resonance imaging (MRI) and impact on subsequent patient management were evaluated. Impact was divided into: (1) major—detection of occult disease or characterisation of indeterminate lesion(s) on CT/MRI; (2) minor—confirmation of suspected metastases seen on CT/MRI; (3) no impact.
Results: One hundred and eleven patients underwent 118 FDG PET-CT scans, including 30 with suspected gallbladder carcinoma and 81 with cholangiocarcinoma. Eighty-nine scans were performed for initial staging, five for restaging following neoadjuvant chemotherapy and 24 for suspected disease recurrence. In 33 cases (28 %), FDG PET-CT had a major impact on subsequent patient management (39 % gallbladder carcinoma, 26 % intrahepatic cholangiocarcinoma and 21 % extrahepatic cholangiocarcinoma). FDG PET-CT had a minor impact in 20 cases (17 %) and no impact in 65 cases (55 %).
Conclusions: By detecting occult metastatic disease and characterising indeterminate lesions, FDG PET-CT can have a major influence on clinical decision-making in primary and recurrent biliary malignancy.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Author(s) 2013. This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. (https://creativecommons.org/licenses/by/4.0/) |
Keywords: | Gallbladder carcinoma; Cholangiocarcinoma; Biliary tumours; 18F-fluoro-2-deoxy-D-glucose positron emission tomography-computed tomography |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Inst of Biomed & Clin Sciences (LIBACS) (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 01 Apr 2019 11:45 |
Last Modified: | 01 Apr 2019 11:45 |
Status: | Published |
Publisher: | Springer Berlin Heidelberg |
Identification Number: | 10.1007/s13244-013-0268-2 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:125555 |