Classical activation of macrophages and vardenafil

Abstract

Inhibitors of phosphodiesterase 5 (PDE5) - sildenafil citrate (Viagra; Pfizer) and vardenafil hydrochloride (Levitra; Bayer/GlaxoSmithKline) - approved for the treatment of erectile dysfunction and pulmonary arterial hypertension also rescue the loss of cystic fibrosis (CF) chloride channel function and the mislocalization of F508del-CFTR in affected tissues in CF. Can PDE5 inhibitors provide a therapeutic strategy which combines ability to correct the basic ion transport defect and to control de-regulated lung inflammation in CF?

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Item Type:	Article
Authors/Creators:	Muimo, R. https://orcid.org/0000-0003-4242-0188
Copyright, Publisher and Additional Information:	© 2017 Portland Press. This is an author produced version of a paper subsequently published in Clinical Science. Uploaded in accordance with the publisher's self-archiving policy.
Keywords:	Immunology & Inflammation; Molecular Bases of Health & Disease; Molecular Interactions
Dates:	Published: June 2017 Published (online): 22 May 2017 Accepted: 19 April 2017
Institution:	The University of Sheffield
Academic Units:	The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Infection, Immunity and Cardiovascular Disease
Depositing User:	Symplectic Sheffield
Date Deposited:	14 Dec 2017 10:51
Last Modified:	03 Aug 2023 08:43
Status:	Published
Publisher:	Portland Press
Refereed:	Yes
Identification Number:	10.1042/CS20170137
Related URLs:	Author
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:125174

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Classical activation of macrophages and vardenafil

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