Johnson, R, Rawson, S orcid.org/0000-0002-2973-2630, McPhillie, M et al. (2 more authors) (2017) The Growing Role of Electron Microscopy in Anti-parasitic Drug Discovery. Current Medicinal Chemistry, 24. ISSN 0929-8673
Abstract
Parasitic diseases are a huge burden on human health causing significant morbidity and mortality. However, parasitic structure based drug discovery programmes have been hindered by a lack of high resolution structural information from parasitic derived proteins and have largely relied upon homology models from mammalian systems. The recent renaissance in electron microscopy (EM) has caused a dramatic rise in the number of structures being determined at high resolution and subsequently enabled it to be thought of as a tool in drug discovery. In this review, we discuss the challenges associated with the structural determination of parasitic proteins. We then discuss the reasons behind the resurgence in EM, how it may overcome some of these challenges and provide examples of EM derived parasitic protein structures. Finally, we discuss the challenges which EM needs to overcome before it is used as a mainstream technique in parasitic drug discovery.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | This is an author produced version of a paper published in Current Medicinal Chemistry. Uploaded in accordance with the publisher's self-archiving policy. The published manuscript is available at EurekaSelect via https://doi.org/10.2174/0929867324666171109120526. |
Keywords: | Electron microscopy, structure based drug design, Plasmodium falciparum, parasitic disease. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds) > Cryo EM, Image Processing (Leeds) The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) |
Funding Information: | Funder Grant number MRC G1000567/1 Wellcome Trust 109158/B/15/A |
Depositing User: | Symplectic Publications |
Date Deposited: | 14 Dec 2017 14:51 |
Last Modified: | 09 Nov 2018 01:38 |
Status: | Published |
Publisher: | Bentham Science |
Identification Number: | 10.2174/0929867324666171109120526 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:125056 |