Mendes, AC, Strohmenger, T, Goycoolea, F orcid.org/0000-0001-7949-5429 et al. (1 more author) (2017) Electrostatic self-assembly of polysaccharides into nanofibers. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 531. pp. 182-188. ISSN 0927-7757
Abstract
In this study, the anionic polysaccharide Xanthan gum (X) was mixed with positively charged Chitosan oligomers (ChO), and used as building blocks, to generate novel nanofibers by electrostatic self-assembly in aqueous conditions. Different concentrations, ionic strength and order of mixing of both components were tested and observed to affect the diameter, which ranged from 100 to 500 nm, and morphology of the self-assembled nanofibers. The release of diclofenac, as model drug, from self-assembled xanthan-chitosan nanofibers was demonstrated, suggesting that these nanostructures can be used in applications within life sciences such as drug delivery.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2017 Elsevier B.V. All rights reserved. This is an author produced version of a paper published in Colloids and Surfaces A: Physicochemical and Engineering Aspects. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Polyssacharide; Chitosan oligomers; Xanthan gum; Self-assembly; Nanofibers; Drug delivery |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 04 Dec 2017 16:35 |
Last Modified: | 14 Jul 2018 00:38 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.colsurfa.2017.07.044 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:124782 |