Chan, H.-F., Stewart, N.J. orcid.org/0000-0001-8358-394X, Norquay, G. et al. (2 more authors) (2018) 3D diffusion-weighted (129) Xe MRI for whole lung morphometry. Magnetic Resonance in Medicine, 79 (6). pp. 2986-2995. ISSN 0740-3194
Abstract
PURPOSE:
To obtain whole lung morphometry measurements from (129) Xe in a single breath-hold with 3D multiple b-value (129) Xe diffusion-weighted MRI (DW-MRI) with an empirically optimized diffusion time and compressed sensing for scan acceleration.
METHODS:
Prospective three-fold undersampled 3D multiple b-value hyperpolarized (129) Xe DW-MRI datasets were acquired, and the diffusion time (Δ) was iterated so as to provide diffusive length scale (LmD ) estimates from the stretched exponential model (SEM) that are comparable to those from (3) He. The empirically optimized (129) Xe diffusion time was then implemented with a four-fold undersampling scheme and was prospectively benchmarked against (3) He measurements in a cohort of five healthy volunteers, six ex-smokers, and two chronic obstructive pulmonary disease patients using both SEM-derived LmD and cylinder model (CM)-derived mean chord length (Lm).
RESULTS:
Good agreement between the mean (129) Xe and (3) He LmD (mean difference, 2.2%) and Lm (mean difference, 1.1%) values was obtained in all subjects at an empirically optimized (129) Xe Δ = 8.5 ms.
CONCLUSION:
Compressed sensing has facilitated single-breath 3D multiple b-value (129) Xe DW-MRI acquisitions, and results at (129) Xe Δ = 8.5 ms indicate that (129) Xe provides a viable alternative to (3) He for whole lung morphometry mapping with either the SEM or CM. Magn Reson Med, 2017. © 2017 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 The Authors Magnetic Resonance in Medicine published by WileyPeriodicals, Inc. on behalf of International Society for Magnetic Resonance inMedicine. This is an open access article under the terms of the CreativeCommons Attribution License, which permits use, distribution and reproductionin any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/ |
Keywords: | compressed sensing; hyperpolarized 129Xe; hyperpolarized 3He; lung morphometry; stretched exponential model |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Infection, Immunity and Cardiovascular Disease |
Funding Information: | Funder Grant number NATIONAL INSTITUTE FOR HEALTH RESEARCH NIHR-RP-R3-12-027 MEDICAL RESEARCH COUNCIL MR/M008894/1 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 24 Nov 2017 11:37 |
Last Modified: | 14 Dec 2023 08:50 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1002/mrm.26960 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:124457 |
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