Mahdi, F orcid.org/0000-0002-3046-4389, Hassanpour, A orcid.org/0000-0002-7756-1506 and Muller, F (2018) An investigation on the evolution of granule formation by in-process sampling of a high shear granulator. Chemical Engineering Research and Design, 129. pp. 403-411. ISSN 0263-8762
Abstract
Understanding the growth mechanisms in granulation process is an important topic, providing valuable insights and supports control strategies. Typically, observations in high shear granulators are made after stopping the process. In this work, an in-process sampling technique is described and applied to a high shear wet granulation process. Different samples can be collected over the cause of the high shear granulation process. This allowed observation of the evolution of granules during addition of water at a constant flowrate. For a typical pharmaceutical formulation, we observed that granules nucleate in the first 2 minutes after water addition starts and then grows in size and strength to an average size of 200–1200 μm at 12.5 minutes, corresponding to a sharp increase in torque. Longer water addition times lead to oversized granules and eventually a paste and highly fluctuating torque. Sampling was continued after stopping water addition which showed with time larger formed granules smoothen, whilst the smaller weaker ones disintegrate. The work shows the in-process sampling can facilitate the identification of the required binder quantity in high shear granulation.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2017 The Authors. Published by Elsevier B.V. on behalf of Institution of ChemicalEngineers. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
Keywords: | Granulation mechanisms; sampling system; image-based techniques; high shear granulation; over wetted and granule size |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemical & Process Engineering (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 15 Nov 2017 16:08 |
Last Modified: | 11 Nov 2018 01:39 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.cherd.2017.10.038 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:124172 |