Dondas, HA, Belveren, S, Poyraz, S et al. (5 more authors) (2018) Design and synthesis of novel 1,4-benzodiazepine surrogates as potential CCKA and CCKB antagonists via palladium-catalyzed three-component cascade reactions. Tetrahedron, 74 (1). pp. 6-11. ISSN 0040-4020
Abstract
Structurally diverse novel 1,4-benzodiazepine analogues related to selective CCKA antagonist MK-329, and CCKB antagonists L-365,260 and YM022 are prepared via palladium-catalyzed three component domino reactions involving allenylation-carbonylation-anion capture in one-pot cascade protocol in good to excellent yields.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 Elsevier Ltd. This is an author produced version of a paper published in Tetrahedron. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Benzodiazepines; Cholecystokinin (CCK) receptor; Palladium; Allenylation; Carbonylation |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 14 Nov 2017 12:29 |
Last Modified: | 08 Nov 2018 01:38 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.tet.2017.11.017 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:124053 |