Dayer, M. and Thornhill, M. orcid.org/0000-0003-0681-4083 (2018) Is antibiotic prophylaxis to prevent infective endocarditis worthwhile? Journal of Infection and Chemotherapy, 24 (1). pp. 18-24. ISSN 1341-321X
Abstract
Infective endocarditis (IE) is a rare condition which is associated with considerable morbidity and mortality. Almost 100 years ago, the links between endocarditis and procedures, particularly dental procedures, were postulated. Over 50 years ago the first guidelines recommending antibiotic prophylaxis (AP), with the aim of preventing IE developing after procedures, were proposed. However, there has only ever been circumstantial evidence in humans that AP prevents IE. The rarity of IE has made a randomised controlled clinical trial impractical to date. This article outlines the history of AP and reviews the evidence base for the use of AP to prevent IE.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 Elsevier. This is an author produced version of a paper subsequently published in Journal of Infection and Chemotherapy. Uploaded in accordance with the publisher's self-archiving policy. Article available under the terms of the CC-BY-NC-ND licence (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
Keywords: | Antibiotic prophylaxis; Dental procedures; Infective endocarditis |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Clinical Dentistry (Sheffield) |
Funding Information: | Funder Grant number Heart Research UK RG2632/13/14 National Institutes for Health (NIH) - National Institute for Dental and Craniofacial Research (NIDCR) 1R03DE023092-01 REVISED |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 14 Nov 2017 16:55 |
Last Modified: | 14 Dec 2023 11:19 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | 10.1016/j.jiac.2017.10.006 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:123995 |