Egbe, N.E., Dornelles, T.O., Paget, C.M. et al. (2 more authors) (2017) Farnesol inhibits translation to limit growth and filamentation in C. albicans and S. cerevisiae. Microbial Cell, 4 (9). pp. 294-304.
Abstract
Candida albicans is a polymorphic yeast where the capacity to switch between yeast and filamentous growth is critical for pathogenicity. Farnesol is a quorum-sensing sesquiterpene alcohol that, via regulation of specific signalling and transcription components, inhibits filamentous growth in C. albicans. Here we show that farnesol also inhibits translation at the initiation step in both C. albicans and S. cerevisiae. In contrast to fusel alcohols, that target the eukaryotic initiation factor 2B (eIF2B), farnesol affects the interaction of the mRNA with the small ribosomal subunit leading to reduced levels of the 48S preinitiation ribosomal complex in S. cerevisiae. Therefore, farnesol targets a different step in the translation pathway than fusel alcohols to elicit a completely opposite physiological outcome by negating filamentous growth.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 Egbe et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged. |
Keywords: | farnesol; protein synthesis; quorum sensing; translation control |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Neuroscience (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 10 Nov 2017 14:38 |
Last Modified: | 10 Nov 2017 14:42 |
Published Version: | https://doi.org/10.15698/mic2017.09.589 |
Status: | Published |
Publisher: | Shared Science Publishers |
Refereed: | Yes |
Identification Number: | 10.15698/mic2017.09.589 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:123869 |
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