Samuelson, C., Kaur, H., Kritsotakis, E.I. orcid.org/0000-0002-9526-3852 et al. (3 more authors) (2018) A daily topical decontamination regimen reduces catheter-related bloodstream infections in haematology patients. Journal of Infection, 76 (2). pp. 132-139. ISSN 0163-4453
Abstract
Objectives. To assess impact of a topical decontamination regimen on rates of catheter-related bloodstream infections (CRBSI) in intensively-treated haematology patients.
Methods. A historically-controlled cohort study was used to evaluate the effect of applying chlorhexidine or Octenisan® body washes and nasal Prontoderm® ointment for 5 days around the time of Hickman line insertion on the incidence of CRBSI and infection-free catheter time. Lines inserted during a 24 month period prior to implementation of the decolonisation regimen were compared with those inserted during a 12 month period after the intervention was applied.
Results. During the post-intervention period, 163 lines were inserted in 147 patients, compared to 303 lines in 242 patients in the pre-intervention period. CRBSI rates in treated and untreated patients respectively were 6.8 and 35.0 cases per 10,000 line-days by 21 days (p = 0.009), and 14.4 and 26.0 cases respectively per 10,000 line-days by 180 days (p = 0.025).
The incidence rate of Staphylococcus aureus CRBSI in treated and untreated patients were 0.0 and 4.6 cases per 10,000 line-days respectively (p = 0.012). Multivariable Cox regression estimated an 81% probability (95% confidence interval 74% - 85%) that a treated line develops a CRBSI later than an untreated line by 21 days post-insertion.
Conclusions. Implementation of this safe and effective topical decontamination regimen enhances routine CRBSI-prevention measures for haematology patients requiring central venous line insertion.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 Elsevier. This is an author produced version of a paper subsequently published in Journal of Infection. Uploaded in accordance with the publisher's self-archiving policy. Article available under the terms of the CC-BY-NC-ND licence (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
Keywords: | Haematology; Catheter-related bloodstream infection; Decolonisation; Chlorhexidine; Prontoderm® |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > ScHARR - Sheffield Centre for Health and Related Research |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 10 Nov 2017 10:24 |
Last Modified: | 14 Dec 2023 14:33 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | 10.1016/j.jinf.2017.10.014 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:123676 |
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Filename: Samuelson et al_J Infection 2017_accepted version.pdf
Licence: CC-BY-NC-ND 4.0