Vanner, S.J., Greenwood-Van Meerveld, B., Mawe, G.M. et al. (4 more authors) (2016) Fundamentals of neurogastroenterology: Basic science. Gastroenterology, 150 (6). pp. 1280-1291. ISSN 0016-5085
Abstract
This review examines the fundamentals of neurogastroenterology that may underlie the pathophysiology of functional GI disorders (FGIDs). It was prepared by an invited committee of international experts and represents an abbreviated version of their consensus document that will be published in its entirety in the forthcoming book and online version entitled Rome IV. It emphasizes recent advances in our understanding of the enteric nervous system, sensory physiology underlying pain, and stress signaling pathways. There is also a focus on neuroimmmune signaling and intestinal barrier function, given the recent evidence implicating the microbiome, diet, and mucosal immune activation in FGIDs. Together, these advances provide a host of exciting new targets to identify and treat FGIDs, and new areas for future research into their pathophysiology.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 The AGA Institute. Published by Elsevier. This is an author produced version of a paper subsequently published in Gastroenterology. Uploaded in accordance with the publisher's self-archiving policy. Article available under the terms of the CC-BY-NC-ND licence (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
Keywords: | Sensory Physiology; Enteric Nervous System; Neuroimmune Signaling; Mucosal Barrier Function |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) > Department of Biomedical Science (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 09 Nov 2017 13:05 |
Last Modified: | 09 Nov 2017 22:03 |
Published Version: | https://doi.org/10.1053/j.gastro.2016.02.018 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | 10.1053/j.gastro.2016.02.018 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:123668 |