Reddy, R.J., Ball-Jones, M.P. and Davies, P.W. (2017) Alkynyl thioethers in gold-catalyzed annulations to form oxazoles. Angewandte Chemie International Edition, 56 (43). pp. 13310-13313. ISSN 1433-7851
Abstract
Non-oxidative, regioselective, and convergent access to densely functionalized oxazoles is realized in a functional-group tolerant manner using alkynyl thioethers. Sulfur-terminated alkynes provide access to reactivity previously requiring strong donor-substituted alkynes such as ynamides. Sulfur does not act in an analogous donor fashion in this gold-catalyzed reaction, thus leading to complementary regioselective outcomes and addressing the limitations of using ynamides.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | cycloaddition; gold; heterocycles; regioselectivity; sulfur |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Chemistry (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 24 Oct 2017 11:55 |
Last Modified: | 17 Nov 2023 15:53 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1002/anie.201706850 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:123017 |
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