Fisher, K.H., Strutt, D. and Fletcher, A.G. orcid.org/0000-0003-0525-4336 (2017) Integrating planar polarity and tissue mechanics in computational models of epithelial morphogenesis. Current Opinion in Systems Biology, 5. pp. 41-49. ISSN 2452-3100
Abstract
Cells in many epithelial tissues are polarised orthogonally to their apicobasal axis. Such planar polarity ensures that tissue shape and structure are properly organised. Disruption of planar polarity can result in developmental defects such as failed neural tube closure and cleft palette. Recent advances in molecular and live-imaging techniques have implicated both secreted morphogens and mechanical forces as orienting cues for planar polarisation. Components of planar polarity pathways act upstream of cytoskeletal effectors, which can alter cell mechanics in a polarised manner. The study of cell polarisation thus provides a system for dissecting the interplay between chemical and mechanical signals in development. Here, we discuss how different computational models have contributed to our understanding of the mechanisms underlying planar polarity in animal tissues, focussing on recent efforts to integrate cell signalling and tissue mechanics. We conclude by discussing ways in which computational models could be improved to further our understanding of how planar polarity and tissue mechanics are coordinated during development.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2017 Elsevier. This is an author produced version of a paper subsequently published in Current Opinion in Systems Biology. Uploaded in accordance with the publisher's self-archiving policy. Article available under the terms of the CC-BY-NC-ND licence (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
Keywords: | Planar polarity; Epithelia; Morphogenesis; Development; Computational models |
Dates: |
|
Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Mathematics and Statistics (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 19 Oct 2017 10:44 |
Last Modified: | 28 Jul 2018 00:38 |
Published Version: | https://doi.org/10.1016/j.coisb.2017.07.009 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | 10.1016/j.coisb.2017.07.009 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:122836 |