Fletcher, A.G. orcid.org/0000-0003-0525-4336, Cooper, F. and Baker, R.E. (2017) Mechanocellular models of epithelial morphogenesis. Philosophical Transactions of the Royal Society B: Biological Sciences, 372 (1720). 20150519. ISSN 0962-8436
Abstract
Embryonic epithelia achieve complex morphogenetic movements, including in-plane reshaping, bending and folding, through the coordinated action and rearrangement of individual cells. Technical advances in molecular and live-imaging studies of epithelial dynamics provide a very real opportunity to understand how cell-level processes facilitate these large-scale tissue rearrangements. However, the large datasets that we are now able to generate require careful interpretation. In combination with experimental approaches, computational modelling allows us to challenge and refine our current understanding of epithelial morphogenesis and to explore experimentally intractable questions. To this end, a variety of cell-based modelling approaches have been developed to describe cell–cell mechanical interactions, ranging from vertex and ‘finite-element’ models that approximate each cell geometrically by a polygon representing the cell's membrane, to immersed boundary and subcellular element models that allow for more arbitrary cell shapes. Here, we review how these models have been used to provide insights into epithelial morphogenesis and describe how such models could help future efforts to decipher the forces and mechanical and biochemical feedbacks that guide cell and tissue-level behaviour. In addition, we discuss current challenges associated with using computational models of morphogenetic processes in a quantitative and predictive way.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2017 The Author(s) Published by the Royal Society. This is an author produced version of a paper subsequently published in Philosophical Transactions B: Biological Sciences. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | epithelial morphogenesis; computational modelling; finite-element model; immersed boundary method; subcellular element model |
Dates: |
|
Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Mathematics and Statistics (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 19 Oct 2017 14:39 |
Last Modified: | 19 Oct 2017 14:47 |
Published Version: | https://doi.org/10.1098/rstb.2015.0519 |
Status: | Published |
Publisher: | The Royal Society |
Refereed: | Yes |
Identification Number: | 10.1098/rstb.2015.0519 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:122834 |