McKeegan, PJ orcid.org/0000-0002-5318-2317 and Sturmey, RG (2012) The role of fatty acids in oocyte and early embryo development. Reproduction, Fertility and Development, 24 (1). pp. 59-67. ISSN 1031-3613
Abstract
Growing evidence suggests that endogenous and exogenous fatty acids play diverse roles in developing mammalian oocytes and early embryos. In this review, we describe some of the regulatory roles of fatty acids in early development, in addition to their metabolic functions. We focus initially on the provision of individual fatty acids, and then discuss how these might affect metabolism, oxidative stress, membrane composition, cell signalling events and gene expression. We propose that ongoing research should focus on physiologically relevant ratios and combinations of fatty acids, rather than isolated individual fatty acids, as their combined roles are both subtle and complex. Changing the ratio of specific fatty acids in the diet of animal models, and in vitro culture medium can cause significant dysregulation of cellular processes and development, an issue that extends to human fertility.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Discovery & Translational Science Dept (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 14 May 2019 15:10 |
Last Modified: | 14 May 2019 15:10 |
Status: | Published |
Publisher: | Commonwealth Scientific and Industrial Research Organization Publishing |
Identification Number: | 10.1071/RD11907 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:122711 |