Rogers, NJ, Jeffery, HC, Claire, S et al. (6 more authors) (2017) Tailoring iridium luminescence and gold nanoparticle size for imaging of microvascular blood flow. Nanomedicine, 12 (22). pp. 2725-2740. ISSN 1743-5889
Abstract
Aim: Imaging of blood flow in narrow channels and close to vessel walls is important in cardiovascular research for understanding pathogenesis. Our aim was to provide novel nanoprobes with visible emission and long lifetimes as trackers of flow. Materials & methods: Gold nanoparticles coated with an iridium complex were prepared. Luminescence imaging was used to monitor their flows in different hematocrit blood and in murine tissues. Results: The velocities are independent of hematocrit level and the nanoparticles entering blood circulation can be clearly detected in vessels in lungs, mesentery and the skeletal muscle. Conclusion: The work introduces for the first time iridium-based yellow-green luminescence with nanoparticle size of 100 nm for visualizing and monitoring flows with much higher resolution than conventional alternatives.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 Zoe Pikramenou. This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/ |
Keywords: | blood flow; gold nanoparticles; imaging; luminescence; metal probes |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 17 Oct 2017 09:35 |
Last Modified: | 28 Mar 2018 21:05 |
Status: | Published |
Publisher: | Future Medicine |
Identification Number: | 10.2217/nnm-2017-0211 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:122462 |