Abuarab, N, Li, F and Sivaprasadarao, A orcid.org/0000-0002-6755-3502 (2017) Ionic signalling and mitochondrial dynamics. Molecular and Cellular Oncology, 4 (6). e1373889. ISSN 2372-3556
Abstract
In age-related diseases, rise in intracellular reactive oxygen species (ROS) causes fragmentation of mitochondrial network. Our recent study demonstrated that ROS activation of TRPM2 (transient receptor potential melastatin-2) channels triggers lysosomal Zn²⁺ release that, in turn, triggers mitochondrial fragmentation. The findings provide new mechanistic insights that may have therapeutic implications.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 Taylor & Francis. This is an Accepted Manuscript of an article published by Taylor & Francis in Molecular & Cellular Oncology on 18 September 2017, available online: http://www.tandfonline.com/10.1080/23723556.2017.1373889. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | calcium; cell proliferation; cell migration; lysosomal membrane permeabilisation; mitochondrial dynamics; oxidative stress; reactive oxygen species; TRPM2; zinc |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 29 Sep 2017 12:16 |
Last Modified: | 18 Sep 2018 00:38 |
Status: | Published |
Publisher: | Taylor & Francis |
Identification Number: | 10.1080/23723556.2017.1373889 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:121884 |