Ilas, DC, Churchman, SM, McGonagle, D et al. (1 more author) (2017) Targeting subchondral bone mesenchymal stem cell activities for intrinsic joint repair in osteoarthritis. Future Science OA, 3 (4). FSO228. ISSN 2056-5623
Abstract
Osteoarthritis (OA) is a common age-related disease with complex pathophysiology. It is characterized by wide-ranging tissue damage and ultimate biomechanical failure of the whole joint. However, signs of tissue adaptation and attempted repair responses are evident in OA-affected osteochondral tissues. Highlighted in this review article is the role of bone-resident mesenchymal stem cells (MSCs) in these bone remodeling responses, and a proposal that targeting MSC activities in OA subchondral bone could represent a novel approach for intrinsic joint regeneration in OA. The development of these therapies will require better understanding of MSC proliferation, migration and differentiation patterns in relation to OA tissue damage and further clarification of the molecular signaling events in these MSCs during disease progression.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 Ilas, Churchman, McGonagle, Jones. This work is licensed under the Creative Commons Attribution 4.0 License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
Keywords: | bone remodeling; mesenchymal; osteoarthritis; stem cells; subchondral bone |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Institute of Rheumatology & Musculoskeletal Medicine (LIRMM) (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 26 Sep 2017 11:55 |
Last Modified: | 22 Mar 2018 09:43 |
Status: | Published |
Publisher: | Future Science |
Identification Number: | 10.4155/fsoa-2017-0055 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:121720 |