Dubacheva, GV, Curk, T, Mognetti, BM et al. (3 more authors) (2014) Superselective Targeting Using Multivalent Polymers. Journal of the American Chemical Society, 136 (5). pp. 1722-1725. ISSN 0002-7863
Abstract
Despite their importance for material and life sciences, multivalent interactions between polymers and surfaces remain poorly understood. Combining recent achievements of synthetic chemistry and surface characterization, we have developed a well-defined and highly specific model system based on host/guest interactions. We use this model to study the binding of hyaluronic acid functionalized with host molecules to tunable surfaces displaying different densities of guest molecules. Remarkably, we find that the surface density of bound polymer increases faster than linearly with the surface density of binding sites. Based on predictions from a simple analytical model, we propose that this superselective behavior arises from a combination of enthalpic and entropic effects upon binding of nanoobjects to surfaces, accentuated by the ability of polymer chains to interpenetrate
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | (c) 2014 American Chemical Society. This ACS article is provided under the terms of this Standard ACS AuthorChoice/Editors’ Choice usage agreement; https://pubs.acs.org/page/policy/authorchoice_termsofuse.html |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) |
Funding Information: | Funder Grant number EU - European Union GA 306435 |
Depositing User: | Symplectic Publications |
Date Deposited: | 12 Mar 2018 12:18 |
Last Modified: | 07 Jun 2023 15:00 |
Status: | Published |
Publisher: | American Chemical Society |
Identification Number: | 10.1021/ja411138s |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:121672 |