Donald, James R orcid.org/0000-0002-2176-4902, Taylor, Richard John Kenneth orcid.org/0000-0002-5880-2490 and Petersen, Wade F (2017) A Low-Temperature, Transition Metal-Free Cross Dehydrogenative Coupling Protocol for the Synthesis of 3,3-Disubstituted Oxindoles. The Journal of organic chemistry. pp. 1-22. ISSN 1520-6904
Abstract
A new low-temperature procedure for the synthesis of 3,3-disubstituted 2-oxindoles via cross dehydrogenative coupling (CDC) is reported. The use of a strong, non-reversible base in these reactions has been found to effect a dramatic drop in reaction temperature (to room temperature) relative to the current state-of-the-art (>100 °C). When employing iodine as an 'oxidant', new evidence suggests that this transformation may occur via a transiently stable iodinated intermediate rather than by direct single-electron oxidation.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 American Chemical Society. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details. |
Keywords: | Journal Article |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 25 Sep 2017 11:00 |
Last Modified: | 05 Jan 2025 00:15 |
Published Version: | https://doi.org/10.1021/acs.joc.7b02085 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1021/acs.joc.7b02085 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:121648 |