Rao, M.R., Stewart, N.J., Griffiths, P.D. orcid.org/0000-0002-2706-5897 et al. (2 more authors) (2018) Imaging human brain perfusion with inhaled hyperpolarized (129)Xe MR imaging. Radiology, 286 (2). ISSN 0033-8419
Abstract
Purpose To evaluate the feasibility of directly imaging perfusion of human brain tissue by using magnetic resonance (MR) imaging with inhaled hyperpolarized xenon 129 ((129)Xe). Materials and Methods In vivo imaging with (129)Xe was performed in three healthy participants. The combination of a high-yield spin-exchange optical pumping (129)Xe polarizer, custom-built radiofrequency coils, and an optimized gradient-echo MR imaging protocol was used to achieve signal sensitivity sufficient to directly image hyperpolarized (129)Xe dissolved in the human brain. Conventional T1-weighted proton (hydrogen 1 [(1)H]) images and perfusion images by using arterial spin labeling were obtained for comparison. Results Images of (129)Xe uptake were obtained with a signal-to-noise ratio of 31 ± 9 and demonstrated structural similarities to the gray matter distribution on conventional T1-weighted (1)H images and to perfusion images from arterial spin labeling. Conclusion Hyperpolarized (129)Xe MR imaging is an injection-free means of imaging the perfusion of cerebral tissue. The proposed method images the uptake of inhaled xenon gas to the extravascular brain tissue compartment across the intact blood-brain barrier. This level of sensitivity is not readily available with contemporary MR imaging methods.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © RSNA, 2017. |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Infection, Immunity and Cardiovascular Disease The University of Sheffield > Sheffield Teaching Hospitals |
Funding Information: | Funder Grant number NATIONAL INSTITUTE FOR HEALTH RESEARCH NIHR-RP-R3-12-027 MEDICAL RESEARCH COUNCIL MR/M008894/1 NATIONAL INSTITUTE FOR HEALTH RESEARCH NIHR-RP-R3-12-027 MEDICAL RESEARCH COUNCIL MR/M008894/1 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 19 Sep 2017 10:51 |
Last Modified: | 07 Nov 2023 08:40 |
Status: | Published |
Publisher: | Radiological Society of North America |
Refereed: | Yes |
Identification Number: | 10.1148/radiol.2017162881 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:121336 |