Guo, L., Vardakis, J.C., Lassila, T. orcid.org/0000-0001-8947-1447 et al. (11 more authors) (2018) Subject-specific multiporoelastic model for exploring the risk factors associated with the early stages of Alzheimer's disease. Interface Focus, 8 (1). ISSN 2042-8898
Abstract
There is emerging evidence suggesting that Alzheimer’s disease is a vascular disorder, caused by impaired cerebral perfusion, which may be promoted by cardiovascular risk factors that are strongly influenced by lifestyle. In order to develop an understanding of the exact nature of such a hypothesis, a biomechanical understanding of the influence of lifestyle factors is pursued. An extended poroelastic model of perfused parenchymal tissue coupled with separate workflows concerning subject-specific meshes, permeability tensor maps and cerebral blood flow (CBF) variability is utilised. The subject-specific datasets used in the modelling of this paper were collected as part of prospective data collection. Two cases were simulated involving male, non-smokers (control and MCI case) during two states of activity (high and low). Results showed a marginally reduced clearance of CSF/ISF, elevated parenchymal tissue displacement and CSF/ISF accumulation and drainage in the MCI case. Peak perfusion remained at 8 mm/s between the two cases.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
Keywords: | Alzheimer’s disease; poroelasticity; finite element method; permeability tensor map; cerebral blood flow; cerebrospinal fluid |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Electronic and Electrical Engineering (Sheffield) |
Funding Information: | Funder Grant number EUROPEAN COMMISSION - FP6/FP7 VPH DARE - 601055 ENGINEERING AND PHYSICAL SCIENCE RESEARCH COUNCIL (EPSRC) EP/M006328/1 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 25 Sep 2017 09:43 |
Last Modified: | 19 Dec 2017 10:48 |
Published Version: | https://doi.org/10.1098/rsfs.2017.0019 |
Status: | Published |
Publisher: | Royal Society, The |
Refereed: | Yes |
Identification Number: | 10.1098/rsfs.2017.0019 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:121216 |