Canning, S.L., Neal, T.J. and Armes, S.P. orcid.org/0000-0002-8289-6351 (2017) PH-Responsive Schizophrenic Diblock Copolymers Prepared by Polymerization-Induced Self-Assembly. Macromolecules, 50 (16). pp. 6108-6116. ISSN 0024-9297
Abstract
Polymerization-induced self-assembly (PISA) is used for the highly convenient and efficient preparation of ampholytic diblock copolymer nanoparticles directly in acidic aqueous solution. Cationic nanoparticles comprising a protonated polyamine stabilizer block and a hydrophobic polyacid core-forming block are formed at pH 2. Micelle inversion occurs at pH 10 to produce anionic nanoparticles with an ionized polyacid stabilizer block and a hydrophobic polyamine core-forming block. Macroscopic precipitation occurs at around pH 6-7, which lies close to the isoelectric point of this ampholytic diblock copolymer. Incorporation of fluorescein and rhodamine dye labels into the acid and amine blocks, respectively, leads to dual-color bifluorescent self-reporting pH-responsive nanoparticles.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2017 American Chemical Society. This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited. |
Dates: |
|
Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Chemistry (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 06 Sep 2017 12:16 |
Last Modified: | 16 Feb 2018 12:14 |
Published Version: | https://doi.org/10.1021/acs.macromol.7b01005 |
Status: | Published |
Publisher: | American Chemical Society |
Refereed: | Yes |
Identification Number: | 10.1021/acs.macromol.7b01005 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:120867 |