Allen, C., Shaw, P.J. and Ferraiuolo, L. orcid.org/0000-0001-9118-5714 (2017) Can astrocytes be a target for precision medicine? In: El-Khamisy, S., (ed.) Personalised Medicine. Advances in Experimental Medicine and Biology (1007). Springer ISBN 978-3-319-60731-3
Abstract
Astrocytes are the most abundant non-neural cell type residing within the central nervous system (CNS) displaying tremendous heterogeneity depending on their location. Once believed to be ‘passive support cells for electrically active neurons’, astrocytes are now recognised to play an active role in brain homeostasis by forming connections with the surrounding neurons, microglia and endothelial cells. Most importantly, they provide an optimum microenvironment for functional neurons through regulation of the blood brain barrier, energy supply and removal of debris and toxic waste.
Their dysfunction has been identified as a potential contributing factor for several neurodegenerative disorders, from Alzheimer’s Disease to Amyotrophic Lateral Sclerosis.
In this chapter, we will explore the implications of astrocyte dysfunction in neurodegenerative diseases and how these cells can be used as therapeutic targets in precision medicine.
Metadata
Item Type: | Book Section |
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Authors/Creators: |
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Editors: |
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Copyright, Publisher and Additional Information: | © American Association of Pharmaceutical Scientists 2017. This is an author produced version of a paper subsequently published in Advances in Experimental Medicine and Biology. Uploaded in accordance with the publisher's self-archiving policy. The final publication is available at Springer via https://doi.org/10.1007/978-3-319-60733-7_7. |
Keywords: | Astrocytes; Neurodegeneration; Inflammation; Non-cell autonomous mechanism; Biomarkers; Transcriptomic analysis; High-throughput screening; Precision medicine |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Neuroscience (Sheffield) |
Funding Information: | Funder Grant number THIERRY LATRAN FOUNDATION FTL AAP 2016 ACADEMY OF MEDICAL SCIENCES SBF002\1142 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 05 Oct 2017 08:57 |
Last Modified: | 21 Mar 2018 16:19 |
Published Version: | https://doi.org/10.1007/978-3-319-60733-7_7 |
Status: | Published |
Publisher: | Springer |
Series Name: | Advances in Experimental Medicine and Biology |
Refereed: | Yes |
Identification Number: | 10.1007/978-3-319-60733-7_7 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:120774 |