Tahir, B.A., Bragg, C.M., Wild, J.M. et al. (5 more authors) (2017) Impact of field number and beam angle on functional image-guided lung cancer radiotherapy planning. Physics in Medicine and Biology, 62 (17). pp. 7114-7130. ISSN 0031-9155
Abstract
To investigate the effect of beam angles and field number on functionally-guided intensity modulated radiotherapy (IMRT) normal lung avoidance treatment plans that incorporate hyperpolarised helium-3 magnetic resonance imaging ((3)He MRI) ventilation data. Eight non-small cell lung cancer patients had pre-treatment (3)He MRI that was registered to inspiration breath-hold radiotherapy planning computed tomography. IMRT plans that minimised the volume of total lung receiving ⩾20 Gy (V20) were compared with plans that minimised (3)He MRI defined functional lung receiving ⩾20 Gy (fV20). Coplanar IMRT plans using 5-field manually optimised beam angles and 9-field equidistant plans were also evaluated. For each pair of plans, the Wilcoxon signed ranks test was used to compare fV20 and the percentage of planning target volume (PTV) receiving 90% of the prescription dose (PTV90). Incorporation of (3)He MRI led to median reductions in fV20 of 1.3% (range: 0.2-9.3%; p = 0.04) and 0.2% (range: 0 to 4.1%; p = 0.012) for 5- and 9-field arrangements, respectively. There was no clinically significant difference in target coverage. Functionally-guided IMRT plans incorporating hyperpolarised (3)He MRI information can reduce the dose received by ventilated lung without comprising PTV coverage. The effect was greater for optimised beam angles rather than uniformly spaced fields.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 Institute of Physics and Engineering in Medicine. This is an author produced version of a paper subsequently published in Physics in Medicine and Biology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | IMRT; NSCLC; radiation therapy; lung avoidance; hyperpolarized helium-3 MRI |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Division of Genomic Medicine (Sheffield) > Department of Oncology and Metabolism (Sheffield) The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 31 Aug 2017 10:09 |
Last Modified: | 11 Aug 2018 00:38 |
Published Version: | https://doi.org/10.1088/1361-6560/aa8074 |
Status: | Published |
Publisher: | IOP Publishing |
Refereed: | Yes |
Identification Number: | 10.1088/1361-6560/aa8074 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:120716 |