Mahon, CS, McGurk, CJ, Watson, SMD et al. (4 more authors) (2017) Molecular Recognition‐Mediated Transformation of Single‐Chain Polymer Nanoparticles into Crosslinked Polymer Films. Angewandte Chemie - International Edition, 56 (42). pp. 12913-12918. ISSN 1433-7851
Abstract
We describe single-chain polymer nanoparticles (SCNPs) possessing intramolecular dynamic covalent crosslinks that can transform into polymer films through a molecular recognition-mediated crosslinking process. The SCNPs utilize molecular recognition with surface-immobilized proteins to concentrate themselves upon a substrate, bringing the SCNPs into close spatial proximity with one another and allowing their dynamic covalent crosslinkers to undergo intra-to interpolymer chain crosslinking leading to the formation of polymeric film. This new approach to polymer film formation presents a potential method to 'wrap' surfaces displaying molecular recognition motifs—which could potentially include viral, cellular and bacterial surfaces or designed artificial surfaces displaying multivalent recognition motifs—within a layer of polymer film.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | adaptive materials; carbohydrates; dynamic covalent chemistry; polymer films; polymer nanoparticles |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) |
Funding Information: | Funder Grant number EPSRC (Engineering and Physical Sciences Research Council) EP/G043302/1 BBSRC (Biotechnology & Biological Sciences Research Council) BB/M005666/1 |
Depositing User: | Symplectic Publications |
Date Deposited: | 30 Aug 2017 10:06 |
Last Modified: | 01 Mar 2021 23:46 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/anie.201706379 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:120630 |