Turner, TD, Halfpenny, PJ and Roberts, KJ orcid.org/0000-0002-1070-7435 (2017) Pharmaceutical solid-state characterisation techniques. In: Engineering Crystallography: From Molecule to Crystal to Functional Form. NATO Science for Peace and Security Series A: Chemistry and Biology . Springer , Dordrecht , pp. 367-393. ISBN 978-94-024-1115-7
Abstract
The solid state of a pharmaceutical material impacts on every aspect of its formulation; from solubility and thermodynamic stability to tabletability and flowability. Due to this fundamental connection characterising the solid state is key to providing the information necessary to reduce possible future manufacturing or formulation issues, which critically cuts drug product development costs and time. In this chapter a summary of the importance of the solid state and solid form screening in the pharmaceutical industry is presented. This is followed by an introduction to some of the solid state characterisation techniques routinely utilised in the pharmaceutical industry together with examples of the information provided by each.
Metadata
Item Type: | Book Section |
---|---|
Authors/Creators: |
|
Keywords: | Analytical techniques; DSC; TGA; XRD; DVS; Infrared spectroscopy; Raman spectroscopy; Particles size and shape characterisation; Solid form selection; Solid state characterisation; Quality by design |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemical & Process Engineering (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 23 Aug 2017 14:43 |
Last Modified: | 23 Aug 2017 14:43 |
Status: | Published |
Publisher: | Springer |
Series Name: | NATO Science for Peace and Security Series A: Chemistry and Biology |
Identification Number: | 10.1007/978-94-024-1117-1_23 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:120447 |