Mahon, Clare S., J. McGurk, Christopher, M. D. Watson, Scott et al. (4 more authors) (2017) Molecular-recognition mediated transformation of single-chain polymer nanoparticles into crosslinked polymer films. Angewandte Chemie International Edition. pp. 12913-12918. ISSN 1433-7851
Abstract
We describe single-chain polymer nanoparticles (SCNPs) possessing intramolecular dynamic covalent crosslinks that can transform into polymer films through a molecular recognition-mediated crosslinking process. The SCNPs utilise molecular recognition with surface-immobilised proteins to concentrate upon a substrate, bringing the SCNPs into close spatial proximity with one another and allowing their dynamic covalent crosslinkers to undergo intra- to interpolymer chain crosslinking leading to the formation of polymeric film. SCNPs must possess both the capacity for specific molecular recognition and a dynamic nature to their intramolecular crosslinkers to form polymer films, and an investigation of the initial phase of film formation indicates it proceeds from features which form upon the surface then grow predominantly in the xy directions. This approach to polymer film formation presents a potential method to “wrap” surfaces displaying molecular recognition motifs—which could potentially include viral, cellular and bacterial surfaces or artificial surfaces displaying multivalent recognition motifs—within a layer of polymer film.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. |
Keywords: | adaptive materials,carbohydrates,dynamic covalent chemistry,polymer films,polymer nanoparticles |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 16 Aug 2017 13:30 |
Last Modified: | 16 Oct 2024 13:59 |
Published Version: | https://doi.org/10.1002/anie.201706379 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1002/anie.201706379 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:120241 |
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