Maldonado, EM, Leoncikas, V, Fisher, CP et al. (3 more authors) (2017) Integration of Genome Scale Metabolic Networks and gene regulation of metabolic enzymes with Physiologically Based Pharmacokinetics. CPT: Pharmacometrics & Systems Pharmacology, 6 (11). pp. 732-746. ISSN 2163-8306
Abstract
The scope of Physiologically Based Pharmacokinetic (PBPK) modelling can be expanded by assimilation of the mechanistic models of intracellular processes from Systems Biology field. Genome Scale Metabolic Networks (GSMNs) represent a whole set of metabolic enzymes expressed in human tissues. Dynamic models of the gene regulation of key drug metabolism enzymes are available. Here, we introduce GSMNs and review ongoing work on integration of PBPK, GSMNs and metabolic gene regulation. We demonstrate example models.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 The Authors. CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | PBPK; GSMN; CBM; FBA; QSSPN; MUFINS; gene regulation; multiscale; systems biology |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 14 Aug 2017 14:54 |
Last Modified: | 23 Jun 2023 22:34 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/psp4.12230 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:120105 |