Stewart, N.J., Norquay, G., Griffiths, P.D. orcid.org/0000-0002-2706-5897 et al. (1 more author) (2015) Feasibility of human lung ventilation imaging using highly polarized naturally abundant xenon and optimized three-dimensional steady-state free precession. Magnetic Resonance in Medicine , 74 (2). pp. 346-352. ISSN 0740-3194
Abstract
Purpose
To demonstrate the potential for high quality MRI of pulmonary ventilation using naturally abundant xenon (NAXe) gas.
Methods
MRI was performed at 1.5 Tesla (T) and 3 T on one healthy smoker and two healthy never-smokers. 129Xe gas was polarized to ∼25% using an in-house spin-exchange optical pumping polarizer fitted with a laser diode array with integrated volume holographic grating and optical train system. Volunteers inhaled 1 L of NAXe for an 8 to 15 s breathhold while MR images were acquired with full-lung coverage using a three-dimensional steady-state free precession sequence, optimized for maximum signal-to-noise ratio (SNR) at a given spatial resolution. For the purpose of image quality comparison, the MR acquisition was repeated at 1.5 T with 400 mL enriched xenon and 200 mL 3He.
Results
All NAXe lung images were of high quality, with mean SNRs of 25–40 (voxel 4.2 × 4.2 × 8/10 mm3) and ∼30% improvement at 3 T versus 1.5 T. The high SNR permitted identification of minor ventilation defects in the healthy smoker's lungs. NAXe images were of comparable SNR to those obtained with enriched xenon and 3He.
Conclusion
Optimization of MR pulse sequences and advances in polarization technology have facilitated high quality pulmonary ventilation imaging with inexpensive NAXe gas. Magn Reson Med 74:346–352, 2015.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | This is the peer reviewed version of the following article: Stewart, N. J., Norquay, G., Griffiths, P. D. and Wild, J. M. (2015), Feasibility of human lung ventilation imaging using highly polarized naturally abundant xenon and optimized three-dimensional steady-state free precession. Magn. Reson. Med., 74: 346–352, which has been published in final form at https://doi.org/10.1002/mrm.25732. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
Keywords: | hyperpolarized gas; naturally abundant xenon-129; lung ventilation imaging; 3D steady-state free precession |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Infection, Immunity and Cardiovascular Disease The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 09 Aug 2017 11:38 |
Last Modified: | 09 Aug 2017 11:48 |
Published Version: | https://doi.org/10.1002/mrm.25732 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1002/mrm.25732 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:119973 |