Armstead, AL, Simoes, TA, Wang, X et al. (5 more authors) (2017) Toxicity and oxidative stress responses induced by nano- and micro-CoCrMo particles. Journal of Materials Chemistry B, 5 (28). pp. 5648-5657. ISSN 2050-750X
Abstract
Metal implants are used routinely during total hip and knee replacements and are typically composed of cobalt chromium molybdenum (CoCrMo) alloys. CoCrMo “wear particles”, in the nano- and micro-size ranges, are generated in situ. Meanwhile, occupational exposure to CoCrMo particles may be associated with the development of industrial dental worker's pneumoconiosis. In this study, we report that both nano- and micro-CoCrMo induced a time and dose-dependent toxicity in various cell types (i.e. lung epithelial cells, osteoblasts, and macrophages), and the effects of particle size on cell viability and oxidative responses were interesting and cell specific. Our findings highlight the potential roles that nano- and micro-CoCrMo, whether exposure is due to inhalation or implant wear, and the associated oxidative stress may play in the increasingly reported implant loosening, osteolysis, and systemic complications in orthopaedic patients, and may explain the risk of lung diseases in dental workers.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | This journal is © The Royal Society of Chemistry 2017. This is an author produced version of a paper published in Journal of Materials Chemistry B. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemical & Process Engineering (Leeds) |
Funding Information: | Funder Grant number EU - European Union NMP4-SL-2009-229244 EU - European Union 262163 EU - European Union 262163 EU - European Union 262163 EU - European Union 262163 |
Depositing User: | Symplectic Publications |
Date Deposited: | 08 Aug 2017 10:49 |
Last Modified: | 15 Jun 2018 00:39 |
Status: | Published |
Publisher: | Royal Society of Chemistry |
Identification Number: | 10.1039/C7TB01372H |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:119880 |