Mitra, B., Hilden, J. and Litster, J.D. orcid.org/0000-0003-4614-3501 (2016) Effects of the granule composition on the compaction behavior of deformable dry granules. Powder Technology, 291. pp. 487-498. ISSN 0032-5910
Abstract
Calibration of the Drucker Prager Cap (DPC) model parameters provides a means for a deeper understanding of the impact of granule composition on the compaction properties of dry granules independent of their solid fraction (SF). In this study, monodisperse granules of mixtures of microcrystalline cellulose and mannitol (0%, 25%, 50%, 75% and 100% mannitol) prepared as small cylindrical compacts with well-defined size, shape and SF (0.58) were used as model dry granules. DPC parameters--namely, cohesion, internal friction angle, cap eccentricity, and hydrostatic yield strength of materials--were determined from the diametrical and uniaxial compression, and in-die compaction tests. Elastic properties such as Young’s modulus and Poisson’s ratios were also determined from the in-die compaction test. Higher level of MNT in granules required a lower compression pressure to obtain a low SF tablet but higher compression pressure to obtain a high SF tablets. Properties such as cohesion and diametrical tensile strength go through a maximum as the mannitol level increases in the binary granules, and clearly do not follow the linear mixing rule. At an industrially-relevant tablet solid fraction of 0.88, granules with 75% mannitol exhibited the highest cohesion, and produced the strongest tablet. Other properties either approximately follow the linear mixing rule (e.g., hydrostatic yield strength, young's modulus and Poisson’s ratio) where some interactions between the constituents are present, or not sensitive to the composition (e.g., internal angle of friction). In general, the compaction behavior of granules of a multicomponent system may not be precisely estimated from the properties of individual components, simply by using the linear mixing rule.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 Elsevier. This is an author produced version of a paper subsequently published in Powder Technology. Uploaded in accordance with the publisher's self-archiving policy. Article available under the terms of the CC-BY-NC-ND licence (https://creativecommons.org/licenses/by-nc-nd/4.0/) |
Keywords: | Dry Granules; Powder Mixture; Tablet; Solid Fraction; Tensile Strength; Drucker-Prager Cap (DPC) Model |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Chemical and Biological Engineering (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 03 Aug 2017 14:21 |
Last Modified: | 06 Aug 2017 04:36 |
Published Version: | https://doi.org/10.1016/j.powtec.2016.01.009 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | 10.1016/j.powtec.2016.01.009 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:119748 |
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