Rashid, A., White, E., Howes, T. et al. (2 more authors) (2017) From Raw Data to Process: The Path to a Batch or a Continuous Crystallizer Design for Ibuprofen. Organic Process Research & Development, 21 (2). pp. 187-194. ISSN 1083-6160
Abstract
To design a crystallizer for producing an active pharmaceutical ingredient (API) of the desired crystal size, it is necessary to know the solubility, the nucleation metastable zone widths (MSZW), the crystal growth rates, and the nucleation rates. These data are available for the popular anti-inflammatory drug ibuprofen crystallized from absolute ethanol and water–ethanol mixtures. Using these data, methods are outlined to design industrial crystallizers to recover ibuprofen crystals. From ethanol, as the solubility increases greatly with temperature, cooling crystallizers can be used industrially. Both seeded batch and continuous designs are considered.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 American Chemical Society. |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Chemical and Biological Engineering (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 03 Aug 2017 14:07 |
Last Modified: | 03 Aug 2017 14:12 |
Published Version: | https://doi.org/10.1021/acs.oprd.6b00339 |
Status: | Published |
Publisher: | American Chemical Society |
Refereed: | Yes |
Identification Number: | 10.1021/acs.oprd.6b00339 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:119746 |