Crandon, S, Elbaz, MSM, Westenberg, JJM et al. (3 more authors) (2017) Clinical applications of intra-cardiac four-dimensional flow cardiovascular magnetic resonance: A systematic review. International Journal of Cardiology, 249. pp. 486-493. ISSN 0167-5273
Abstract
Background: Four-dimensional flow cardiovascular magnetic resonance (4D flow CMR) is an emerging non-invasive imaging technology used to visualise and quantify intra-cardiac blood flow. The aim of this systematic review is to assess the literature on the current clinical applications of intra-cardiac 4D flow CMR. Methods: A systematic review was conducted to evaluate the literature on the intra-cardiac clinical applications of 4D flow CMR. Structured searches were carried out on Medline, EMBASE and the Cochrane Library in October 2016. A modified Critical Skills Appraisal Programme (CASP) tool was used to objectively assess and score the included studies. Studies were categorised as ‘highly clinically applicable’ for scores of 67–100%, ‘potentially clinically applicable’ for 34–66% and ‘less clinically applicable’ for 0–33%. Results: Of the 1608 articles screened, 44 studies met eligibility for systematic review. The included literature consisted of 22 (50%) mechanistic studies, 18 (40.9%) pilot studies and 4 (9.1%) diagnostic studies. Based on the modified CASP tool, 27 (62%) studies were ‘highly clinically applicable’, 9 (20%) were ‘potentially clinically applicable’ and 8 (18%) were ‘less clinically applicable’. Conclusions: There are many proposed methods for using 4D flow CMR to quantify intra-cardiac flow. The evidence base is mainly mechanistic, featuring single-centred designs. Larger, multi-centre studies are required to validate the proposed techniques and investigate the clinical advantages that 4D flow CMR offers over standard practices.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the terms of the Creative Commons Attribution License (CC-BY 4.0), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
Keywords: | Intra-cardiac; Systematic review; Four-dimensional; 4D flow CMR; 4D flow MRI; Cardiovascular magnetic resonance |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Division of Biomedical Imaging (Leeds) |
Funding Information: | Funder Grant number British Heart Foundation FS/10/062/28409 |
Depositing User: | Symplectic Publications |
Date Deposited: | 27 Jul 2017 13:51 |
Last Modified: | 23 Mar 2018 12:28 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.ijcard.2017.07.023 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:119550 |