Borgna, SC, Clarke, PT, Scache, AG et al. (11 more authors) (2017) Management of proliferative verrucous leukoplakia: Justification for a conservative approach. Head and Neck, 39 (10). pp. 1997-2003. ISSN 1043-3074
Abstract
Background: Proliferative verrucous leukoplakia (PVL) is a progressive, multifocal, exophytic form of leukoplakia with high rates of malignant transformation. The purpose of this study was to evaluate a cohort of patients with PVL in a single tertiary referral clinic. Method: Cases meeting accepted diagnostic criteria were reviewed with regard to their pathology, demographic characteristics, management, and outcomes. Human papillomavirus (HPV) testing was undertaken on a subset. Results: Almost half of the 48 patients with PVL (48%; n = 23) underwent malignant transformation after a median 23.4 months. The characteristics of this cohort were similar to those previously described, but management was notably more conservative. Conservative management of PVL was used in 92% of our patients, but the clinical outcomes seem comparable with previously described cohorts in which PVL was predominantly treated by surgical excision. All HPV testing was negative. Conclusion: Aggressive surgical intervention in the premalignant phase of PVL may not influence the rate of malignant transformation.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2017 Wiley Periodicals, Inc. This is the peer reviewed version of the following article: Borgna SC, Clarke PT, Schache AG, et al. Management of proliferative verrucous leukoplakia: Justification for a conservative approach. Head & Neck. 2017;00:1–7. https://doi.org/10.1002/hed.24845, which has been published in final form at https://doi.org/10.1002/hed.24845. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | proliferative verrucous leukoplakia; management; malignant |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Dentistry (Leeds) > School of Dentistry Visitors (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 25 Jul 2017 10:47 |
Last Modified: | 22 Jun 2018 00:38 |
Status: | Published |
Publisher: | John Wiley & Sons Inc. |
Identification Number: | 10.1002/hed.24845 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:119372 |