Bilitewski, Ursula, Blodgett, Joshua A.V., Duhme-Klair, Anne Kathrin orcid.org/0000-0001-6214-2459 et al. (4 more authors) (2017) Chemical and Biological Aspects of Nutritional Immunity - Perspectives for New Anti-infectives Targeting Iron Uptake Systems:Perspectives for New Anti-infectives Targeting Iron Uptake Systems. Angewandte Chemie International Edition. pp. 2-25. ISSN 1433-7851
Abstract
Upon bacterial infection, one of the defense mechanisms of the host is the withdrawal of essential metal ions, in particular iron, which leads to "nutritional immunity". However, bacteria have evolved strategies to overcome iron starvation, for example, by stealing iron from the host or other bacteria through specific iron chelators with high binding affinity. Fortunately, these complex interactions between the host and pathogen that lead to metal homeostasis provide several opportunities for interception and, thus, allow the development of novel antibacterial compounds. This Review focuses on iron, discusses recent highlights, and gives some future perspectives which are relevant in the fight against antibiotic resistance.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © Wiley, 2017. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details |
Keywords: | Antibiotics,Heme proteins,Iron,Nutritional immunity,Siderophores |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Funding Information: | Funder Grant number EPSRC EP/L024829/1 |
Depositing User: | Pure (York) |
Date Deposited: | 24 Jul 2017 08:45 |
Last Modified: | 21 Jan 2025 17:25 |
Published Version: | https://doi.org/10.1002/anie.201701586 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1002/anie.201701586 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:119363 |
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Filename: Laschat_et_al_2017_Angewandte_Chemie_International_Edition.pdf
Description: Chemical and Biological Aspects of Nutritional Immunity – Perspectives for New Anti-infectives Targeting Iron Uptake Systems