West, C and McDermott, MF (2017) Effects of microRNA-146a on the proliferation and apoptosis of human osteochondrocytes by targeting TRAF6 through the NF- κB signalling pathway. Bioscience Reports, 37 (4). BSR2017018. ISSN 0144-8463
Abstract
MicroRNAs are important cellular mediators of mRNA degradation and translation repression, which in turn can have an impact on various processes and, if their function is perturbed, can cause disease. Here, we summarize the recent manuscript by Zhong et al. [(2017) Biosci. Rep. 37, BSR20160578], which explores microRNA-146a and how it may play an indirect yet vital role in the proliferation of osteoarthritis (OA) chondrocytes. The data presented by the authors could have important implications for future OA therapies.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 The Author(s). This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY). |
Keywords: | MicroRNA-146a; NF- κB; Osteoarthritis; osteochondrocytes |
Dates: |
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Institution: | The University of Leeds |
Depositing User: | Symplectic Publications |
Date Deposited: | 24 Jul 2017 10:57 |
Last Modified: | 24 Jul 2017 10:57 |
Status: | Published |
Publisher: | Portland Press |
Identification Number: | 10.1042/BSR20170180 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:119316 |